Optimization of fermentation conditions and capsule formulation for enhanced bioactive compound delivery from medicinal mushrooms

Title : Optimization of fermentation conditions and capsule formulation for enhanced bioactive compound delivery from medicinal mushrooms

Abstract:

The enduring history of medicinal mushroom use in traditional healing practices, dating back to the Neolithic era, highlights their age-old recognition for nutritional and therapeutic benefits. These fungi offer a broad spectrum of potential health benefits, such as antimicrobial, antiviral, cytotoxic, immunomodulatory, anti-inflammatory, antioxidant, antiallergic, mood-stabilizing, lipid/glucose control, and blood pressure regulation. The four fungi were grown on defined media (4% C, 0.2% N sources, minerals, 2% agar). Submerged fermentation, followed by HPLC, was used to analyse the impact of varying C/N sources on mycelial growth and secondary metabolites. Proximate analysis and antioxidant activity were performed on individual and combined fungal extracts. Response Surface Methodology (RSM) was utilized to optimize mycelial proliferation in relation to temperature, pH, and carbon-to-nitrogen ratio. Finally, a combined capsule formulation of all fungal extracts was developed, aiming to provide a synergistic health boost by maximizing the benefits of diverse secondary metabolites. Encapsulation offers convenient and precise dosing, masks unpleasant taste, improves absorption, ensures quality, extends shelf life, and enables targeted release, potentially offering advantages over traditional tea, coffee, or powder formulations. Intensive scientific research could pave the way for the mainstream adoption of medicinal mushroom capsules in healthcare.

Biography:

She is currently pursuing Ph.D. on topic “Bioprospecting Cordyceps militaris and Developing Shelf-Stable Pearl Millet: Novel Strategies for Enhanced Medicinal Applications and Nutritional Interventions in Mid-Day Meal Programs” under the guidance of Prof. Anil Sindhu from DCRUST, Murthal, Haryana, India. She has done Masters in zoology from M.D.U, Haryana, India. And Bachelors in Science from M.D.U. as well. She has cleared NET JRF(National Eligibility Test ) for Ph.D. admission with All India Rank 12. Her interests are Research on various aspects of medicinal mushrooms and their bioactives as there is a lot to be known due to less exposure to scientific research